5 Simple Techniques For https://www.ceesdekker.net

5 Simple Techniques For https://www.ceesdekker.net

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‘The second is nanopores, which can be our oldest line of analysis and which has now led to DNA sequencers depending on nanopores. We pull particular person DNA strands by way of a nanopore and might then go through off the nucleotide sequence. Extremely not too long ago, we even managed to go through out just one protein for the first time using This system. But this line of exploration is not simply about establishing resources, but also about real Organic issues.

It had been only during the 1990s nevertheless, when nanotechnology had State-of-the-art to some stage where solitary molecules can be manipulated, that the initial experimental equipment began to seem.

, Groningen scientists current the final results in their endeavours to make labs much more sustainable and provide strategies for other labs. 

I am able to hardly consider how I, as being a geneticist, would have the ability to understand fundamental physics, let alone contend at the very best. How did you go over it?

2015, discovery that condensin is actually a highly adaptable protein construction; and first detection of DNA knots applying nanopores

The coiled-coil in the human Rad50 DNA repair protein incorporates distinct segments of elevated adaptability

We use nanofabricated microfluidic buildings to sample spatial boundaries for microbes and biomimetic vesicles with reconstituted ceesdekker protein networks which evaluate the elemental function of spatial confinement in the molecular and cellular amount. Our projects include the following:

2011, to start with in vitro measurements of transport throughout one biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

2003, shown the 1st biosensors designed away from a carbon nanotube; settled the structure and system of DNA repair service proteins; and discovery of a whole new approach for fabricating stable-point out nanopores for DNA translocation

Dekker began his investigate on solitary carbon nanotubes in 1993 when he setup a completely new line of exploration to study electrical transportation by means of one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was attained in a collaboration While using the group of Nobel laureate Richard Smalley. STM and nanolithography techniques ended up used to display that these nanotubes are quantum wires at The only-molecule amount, with exceptional Actual physical Homes.

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Nanoscientist Cees Dekker can be an amiable and flamboyant person who seems Significantly younger than the sixty two several years he truly is – fashionable Eyeglasses, psychedelic shirt, participating smile – but not a person to waste time. He requires his time, but not more than important.

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Illustration (two) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim with the pore is highlighted in red, and a 3D rendering on the motion with the DNA rod is displayed.